Modeling Neonatal Thimerosal Exposure in Mice
نویسندگان
چکیده
منابع مشابه
Low-level neonatal thimerosal exposure: further evaluation of altered neurotoxic potential in SJL mice.
Ethylmercury in thimerosal-preserved childhood vaccines has been suggested to be neurotoxic and to contribute to the etiology of neurodevelopmental disorders, including autism. Immune system function may be an important factor influencing vulnerability of the developing nervous system to thimerosal. This possibility is based in part on a report by Hornig et al. (2004, Mol. Psychiatry 9, 833-845...
متن کاملModeling neurodevelopment outcomes and ethylmercury exposure from thimerosal-containing vaccines.
Dear Editor, The neurotoxic effects of ethylmercury (EtHg) accidentally consumed in Iraq were sufficient to withdraw ethylmercurycontaining fungicides as seed dressing. Despite that, not only did thimerosal continue to be used in pharmaceutical preparations but also toxicological interest in EtHg-derived substances diminished considerably and was never addressed with regard to the small quantit...
متن کاملThimerosal distribution and metabolism in neonatal mice: comparison with methyl mercury.
Thimerosal, which releases the ethyl mercury radical as the active species, has been used as a preservative in many currently marketed vaccines throughout the world. Because of concerns that its toxicity could be similar to that of methyl mercury, it is no longer incorporated in many vaccines in the United States. There are reasons to believe, however, that the disposition and toxicity of ethyl...
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Background. Selective serotonin reuptake inhibitor (SSRI) therapy complicates up to 10% of pregnancies. During therapy, SSRIs exert pleiotropic antidepressant, anorexigenic, and neurotrophic effects. Intrauterine SSRI exposure has been modeled by neonatal administration to developmentally immature rodents, and it has paradoxically elicited features of adult depression. We hypothesized neonatal ...
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In rodents, neonatal sevoflurane exposure induces neonatal apoptosis in the brain and results in learning deficits. Sugammadex is a new selective neuromuscular blockade (NMB) binding agent that anesthesiologists can use to achieve immediate reversal of an NMB with few side effects. Given its molecular weight of 2178, sugammadex is thought to be unable to pass through the blood brain barrier (BB...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2008
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kfn051